Name: ZHANG Ying

Subject: Development Biology

Tel/Fax: +86-10-64807182/+86-10-64807310

E-mail: zhangying@ioz.ac.cn

Address: D226, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China

Resume

I got my bachelor degree at Beijing Normal University, and a Ph.D degree at Institute of Zoology, Chinese Academy of Sciences, and continue my research in this institute as assistant professor and now associate professor. My research interest is focusing on the molecular/biomechanical mechanism to control intrauterine embryo localization, embryo implantation and pregnancy success. I also developed a keen interest in studying a novel class of tRNA-derived small RNA (tsRNAs) and their associated RNA modifications, and is currently focusing on their functions in mediating uterine-embryo communications as well as their involvement in regulating environment-induced epigenetic inheritance.

2016-Present, Institute of Zoology, Chinese Academy of Sciences，Associate Professor

2011-2015, Institute of Zoology, Chinese Academy of Sciences，AssistantProfessor

2005-2011, Institute of Zoology, Chinese Academy of Sciences，Ph.D

2001-2005, Department of Biology, Beijing Normal University, Bachelor

Research Interests

Embryo implantation and small RNA research.

Awards and Honors

2015, Elected as Fellow of Youth Innovation Promotion Association, Chinese Academy of Science

2015, Young scientist award, Reproductive Biology Committee, Chinese Association of Physiological Science

2015, Science and Technology Progress Award in Maternal and Child Health, First class

2011, Science and Technology Progress Award in reproductive biology, First class, Population and Birth control commission of China

Professional Activities

Ad Hoc Journal Reviewer:

Currently act as an ad hoc reviewer for Journal of Biological Chemistry, scientific reports, Fertility & Sterility, PloS ONE, Cell Biology International, et.al.

Research Grants

1. Funding Source: National Natural Science Foundation of China (Grant No.31671201 )

Project name: Embryo implantation site released exosomal small RNAs regulate ovarian steroidogenesis for early pregnancy establishment

2. Funding Source: Ministry of Science and Technology of China (Grant No. 2015CB943003)

Project name: Functions of sperm non-coding RNA

3. Funding Source: Ferring Institute of Reproductive Medicine (FIRM)

4. Project name: Regulation of early pregnancy

Selected Publications

1. Qian J, Zhang Y, Qu Y, Zhang L, Shi J, Zhang X, Liu S, Bo H, Sung J, Zhou T, Chen Q, Sean M, Duan E^*, Zhang Y^*. (2018). Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice. Biol Reprod. 99(6).

2. Zhang Y^#, Zhang X^#, Shi J^#, Tuorto F^#, Li X^#, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y^*, Zhou Q^*, Duan E^*, Chen Q^*. (2018). Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat Cell Biol. 20:535-540. ( Highlighted in Nat Rev Endo.)

3. Zhang Y^#, Wang Q^#, Wang H, Duan E. (2017). Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends Mol Med. 23(7):604-614. (Highlighted in Cell Press & highlighted in F1000)

4. Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng G, Peng H, Zhang X, Zhang Y, Qian J, Duan E^*, Zhai Q^*, Zhou Q^*. (2016). Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 351(6271):397-400.

5. Zhang Y^#, Chen Q^#, Zhang H^#, Wang Q^#, Li R, Jin Y, Wang H, Ma T, Qiao J, Duan E. (2015). Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res. 25(1):139-42.

6. Shi J, Chen Q, Li X, Zheng X, Zhang Y, Qiao J, Tang F, Tao Y, Zhou Q, Duan E. (2015). Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. Development. 142:3468-3477.

7. Zhang Y^#, Zhang Y^#, Shi J^#, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen ZJ, Chen Q, Duan E. (2014). Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. J Mol Cell Biol. 6 (2):172-174. (Cover Story & Editor’s Recommendation)

8. Chen Q^#, Zhang Y^#, Elad D, Jaffa AJ, Cao Y, Ye X, Duan E. (2013). Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution. Mol Aspects Med. 34(5):1024-42.

9. Lu S^#, Peng H^#, Zhang H^#, Zhang L, Cao Q, Li R, Zhang Y^*, Yan L^*, Duan E, Qiao J. (2013). Excessive intrauterine fluid cause aberrant implantation and pregnancy outcome in mice. PloS One. 8(10):e78446.

10. Zhang H^#, Zhang Y^#, Zhao H, Zhang Y, Chen Q, Peng H, Lei L, Qiao J, Shi J, Cao Z, Duan E, Jin Y. (2013). Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins. PLoS One. 8(5):e63823.

11. Chen Q^#, Zhang Y^#, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E. (2011). Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. J Biol Chem. 286:4349-4356.

12. Zhang Y^#, Zhao H, Peng H, Hu Z, Ning L, Cao Y, Tan Y, Duan E. (2011). GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of mouse prostate. Urology. 77(4):6.

13. Peng H^#, Zhang Y^#, Lei L^#, Chen Q, Yue J, Tan Y, Duan E. (2011). Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertil Steril. 95:1514-1517.

14. Zhang Y^#, Peng S, Kuang H, Chen Q, Liu S, Zhang L, Duan E. (2009). Expression and regulation of Dickkopf2 during periimplantation in mice. J Reprod Dev. 55:17-22.

15. Chen Q^#, Zhang Y^#, Lu J, Wang Q, Wang S, Cao Y, Wang H, Duan E. (2009). Embryo-uterine cross-talk during implantation: the role of Wnt signaling. Mol Hum Reprod. 15:215-221.

16. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H. (2014). Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res. 24(8):925-42.

17. Zhang S, Hu H, Zhang H, Liu S, Liu S, Zhang Y, Lei X, Ning Li, Cao Y, and Duan E. (2012). Hair follicle stem cells derived from single rat vibrissa via organ culture reconstitute hair follicles in vivo. Cell Transplantation. 21(6):1075-85.

18. Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q, Duan E. (2012). A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm. Cell Res. 22:1609-1612.

19. Zhao P, Qiao J, Huang S, Zhang Y, Liu S, Yan LY, Hsueh AJ, Duan E. (2011). Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells. Hum Reprod. 26(3):695-702.

20. Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E. (2011). Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration. Cell Res. 21:922-933.

21. Kuang H, Chen Q, Fan X, Zhang Y, Zhang L, Peng H, Cao Y, Duan E. (2009). CXCL14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice. J Cell Physiol. 221:448-457.

22. Kuang H, Chen Q, Zhang Y, Zhang L, Peng H, Ning L, Cao Y, Duan E. (2009). The cytokine gene CXCL14 restricts human trophoblast cell invasion by suppressing gelatinase activity. Endocrinology. 150:5596-5605.

23. Zhang L, Guo W, Chen Q, Fan X, Zhang Y, Duan .(2009). Adam12 plays a role during uterine decidualization in mice. Cell Tissue Res. 338:413-421.

24. Chen Q, Peng H, Zhang Y, Lei L, Cao Y, Duan E. (2009). Embryo implantation: a time for recalling and forwarding.Chinese Science Bulletin. 54:4083-4093.

25. Peng S, Li J, Miao C, Jia L, Hu Z, Zhao P, Li J, Zhang Y, Chen Q, Duan E. (2008). Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction. 135:367-375.

26. Li J, Liu W, Cao Y, Peng S, Zhang Y, and Duan E. (2008). Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertility and Stertility. 90(4):1470-1479.