LI<br> Lei----INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES

LI
Lei

Date：2018-08-28 [close]

Name: LI Lei

Subject: Developmental Biology

Tel/Fax: +86-10-64807865

Address: The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China

Resume

Lei Li obtained his BS from China Agricultural University in 1994 and his Ph.D. from Gunma University Graduate School of Medicine in Japan in 2002. In 2003, he became a visiting fellow, then as a research fellow at National Institutes of Health (NIH) in USA where he mainly worked on mouse pre-implantation embryogenesis and ovarian development in the laboratory of Jurrien Dean. He established his independent research group in 2009 at the State Key Laboratory of Stem Cell and Reproductive Biology, Institutes of Zoology/Chinese Academy of Sciences. By using genetics, embryo culture and ES cells as model systems, Dr. Li's researches focus on molecular basis of early embryonic development.

Research Interests

1) Maternal control of mammalian early embryogenesis.

2) Cell lineage specification of early embryonic development.

3) Molecular mechanism of mammalian gametogenesis.

Awards and Honors

1) NIH Fellows Award for Research Excellence (NIH, USA), 2007-2008

2) Scientific Director Fellowship Award (NIDDK/NIH, USA), 2005

3) NIH Visiting Fellowship (NIH, USA), 2003-2008

4) Postdoctoral Fellowship for Foreign Researchers (JSPS, Japan), 2002-2003

5) Yoneyama Doctor Course Scholarship (Rotary Yoneyama Memorial Foundation, Japan), 2001-2002

Research Grants

The National Basic Research Program of China (2011CB944501), 2011-2016.

National Natural Science Foundation of China (30971655), 2010-2012.

Selected Publications

1. Lu X, Gao Z, Qin D, Li L^*. (2017). A maternal functional module in the mammalian oocyte-to-embryo transition. Trends in Molecular Medicine. 23(11):1014-1023.

2. Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L^*. (2017). ZBED3 participates in the subcortical maternal complex and regulates the distribution of organelles. Journal of Molecular Cell Biology. 10(1):74-88.

3. Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S. (2017). MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. Journal of Endocrinology. 234(1):1-14.

4. Nie X, Lu X, Li L^*. (2017). First cell lineage specification in mammalian early development (in Chinese). Chinese Science Bulletin. 62(15):1569-1577.

5. Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S^*, Yi Z^*, Li L^*. (2017). BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 8:14182.

6. Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J^*, Yi Z^*, and Li L^*. (2107). Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journal of Biological Chemistry. 292(4):1438-1448.

7. Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L^*. (2016). BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis.Journal of Molecular Cell Biology. 8(4):366-368.

8. Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q^*, Li L^*. (2016). MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-right Determination Factor 2. Journal of Biological Chemistry. 291(23):12126-12135.

9. Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S^*, Li L^*. (2015). Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 142(22):3943-3953.

10. Zhao Z-A, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y, Zhang X-X, Wang H, Li L^*. (2015). The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biology. 5(8).

11. Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P. (2015). Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 16(6):684-698.

12. Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J^*, Li L^*. (2015). Identification of a human subcortical maternal complex. Molecular Human Reproduction. 21(4):320-329.

13. Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J^*, Li L^*. (2014). The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications. 5:4887.

14. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q^*, Duan E^*, Wang H^*. (2014). Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research. 24(8):925-942.

15. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F^*, Gao S^*, Wang H^*. (2014). Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biology of Reproduction. 90(3):52, 1-11.

16. Li L^*, Lu X and Dean J^*. (2013). The maternal to zygotic transition in mammals. Molecular Aspects of Medicine. 34(5):919-938.

17. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z^*. (2013). WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. The EMBO Journal. 32(20):2685-2696.

18. Wang J, Xu M, Zhu K, Li L^*, Liu X^*. (2012). The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE. 7(1):e30209.

19. Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q^*. (2012). Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS ONE. 7(1):e29735.

20. Li L^*, Zheng P and Dean J^*. (2010). Maternal Control of Early Mouse Development. Development. 137(6):859-870.

21. Li L^*, Baibakov B and Dean J. (2008). A Subcortical Maternal Complex Essential for Pre-implantation Mouse Embryogenesis. Developmental Cell. 15(3):416-425.

22. Ohsugi M, Zheng P, Baibakov B, Li L, and Dean J^*. (2008). Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 135(2):259-269.

23. Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I^*. (2004). Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas. Diabetes. 53(10):2596-2602.

24. Li L, Yi Z, Seno M, and Kojima I^*. (2004). Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats. Diabetes. 53(3):608-615.

25. Li L, Seno M, Yamada H, and Kojima I^*. (2003). Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, American Journal of Physiology-endocrinology and Metabolism. 285(3):E577-E583.

26. Li L, Seno M, Yamada H, and Kojima I^*. (2001). Promotion of β-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats. Endocrinology.142(12):5379-5385.