Name: HUANG Shi-Qiang

Tel: 64807869

Email: huangsq@ioz.ac.cn

Education

2005-2008 A.B., Molecular Biology, Princeton University, Princeton, NJ

2009-2013 Ph.D., Biomedical Sciences,Harvard Medical School, Cambridge, MA

Working Experience

2013-2018 Junior PI, Genome Institute of Singapore, ASTAR

2018-present Professor, PI, Regenerative Metabolism Group, Institute of Zoology, CAS

Selected Publications

1. Wu, L.^*, Nguyen L.H.^*, Zhou, K., de Soysa, T.Y., Li, L., Miller, J.B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M.T., Zeitels, L.R., Acharya, A., Wang, S.C., Mendell, J. T., He, X., Nishino, J., Morrison, S.J., Siegwart, D.J., Daley, G.Q., Shyh-Chang, N., Zhu, H. (2015). Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife. 4:e09431.

2. Khaw, S.L., Min-Wen, C., Koh, C.G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports.12(7):1080-1088.

3. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone,Heart,and Other Mesoderm Cell Types. Cell. 166(2):451-467.

4. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends in Endocrinology & Metabolism. 27(3):132-141.

5. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. 52:110-118.

6. Fukawa, T., Yan-Jiang, B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016). Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia.Nature Medicine. 22(6):666-671.

7. Andriani Y^*, Chua JM^*, Chua BY, Phang IY, Shyh-Chang N^#, Tan WS^#. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57:115-126.

8. Shyh-Chang N and Ng H-H. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4):336-346.

9. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5):412-414.

10. Shyh-Chang N. (2018). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026:233-249.