Name: ZHAO Tong-Biao

Tel: +86-10-64806307

Email: tbzhao@ioz.ac.cn

Address

The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China.

Resume

Dr. Tong-biao Zhao received his Ph.D. from Northwest Institute of Plateau Biology, Chinese Academy of Sciences in 2004. He conducted his postdoctoral research and promoted to an associate professor position in 2006 at Institute of Biophysics, Chinese Academy of Sciences. He was then trained at University of California San Diego as a postdoctoral fellow first and then a research specialist from 2007 to 2012. He joined the Institute of Zoology, Chinese Academy of Sciences as a principal investigator sponsored by a scholarship of “National Thousand Youth Talents” program in 2012, and established the Laboratory of Stem Cells and Immunology.

Awards and Honors

2012 SCOPUS Young Researcher Award

Professional Activities:

2012-Present A member of International Society of Stem Cell Research (ISSCR)

2013-Present A member of Chinese Society of Cell Biology (CSCB) and Group leader of standard working group

2017-Present Experts of ISO/TC 276

Editor of Journal of Developmental Medicine

Editor of Animal Models and Experimental Medicine

Editor of Chinese Science Bulletin

Selected Publications

1. Zhou J., Jin L, Wang F, Zhang Y, Liu B, Zhao T. (2019). Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell. 10:764-769.

2. Gu H., Shi X., Liu C., Wang W., Shi N, Zhao Y, Gong J, Wang F, Zhang H, Li W, Zhao T. (2019). USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications. 10(1).

3. Gong J., Gu H., Zhao L., Wang L, Liu P, Wang F, Xu H, Zhao T. (2018). Phosphorylation of ulk1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death & Disease. 9(2):38.

4. Liu P., Liu K., Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T. (2017). High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death and Differentiation. 24(10):1672-1680.

5. Sun H., Cao J., Zhao L., Zhu S, Chen S, Li Y, Zhao B, Zhao, T. (2017). PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin. 62(10):679-685. (Cover story).

6. Liu K., Zhao Q., Liu P., Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou, Q, Zhao, T. (2016). ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy. 12(11):2000-2008.

7. Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao, T. (2016). p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports. 6:31085.

8. Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q., Zhao, T. (2016). Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences. 59(9):950-957.

9. Zhao T., Zhang Z., Westenskow P., Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu, Y. (2015). Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell. 17(3):353-359.

10. Wang L., Cao J., Wang Y., Lan T., Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi, Z, Zhao, T, Zhou, Q. (2015). Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery. 1:15015.

11. Zhao T, Zhang Z, Rong Z, Xu, Y. (2011). Immunogenicity of induced pluripotent stem cells. Nature. 474(7350):212-216.

o Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670).

o Recommended by Faculty of 1000 (F1000.com/11136956).

o Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.

Reviews

1. Wang L., Ye X., Zhao, T. The physiological roles of autophagy in the mammalian life cycle. (2019). Biological Reviews. 94:503-516.

2. Cao J, Zhao T^*. (2016). Single-cell sequencing delivers hematopoietic stem cell specification. Science Bulletin. 61(18):1419-1421.

3. Liu K., Song Y., Yu H, Zhao, T. (2104). Understanding the roadmaps to induced pluripotency. Cell Death & Disease. 5(5):e1232.

4. Cao J., Li X., Lu X, Zhang C, Yu H, Zhao, T. (2014). Cells derived from iPSC can be immunogenic–Yes or No? Protein Cell. 5(1):1-3.

5. Lu X, Zhao, T. (2013). Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics. 11(5):294-298.

6. Zhao T, Xu, Y. (2010). p53 and stem cells: new developments and new concerns. Trends in Cell Biology. 20(3):170-175.