EDUCATION AND RESEARCH EXPERIENCE

Undergraduate and graduate education

1998-2002    School of Life Sciences, Lanzhou University, Lanzhou, China    B.S. , Biochemistry

2002-2007    Institute of Biophysics, CAS                                                        Ph.D. , Cell Biology    Supervisor: Chang Chen

Postdoctoral training

2007-2010    Del E. webb Neuroscience, aging and stem cell research center, Sanford/Burnham Medical Research Institute, CA, U.S.A.

Postdoctoral Fellow    Supervisor: Stuart Lipton

2010-2012    Gene expression lab, The Salk Institute for Biological Research, CA, U.S.A. 

Research Associate    Supervisor: Juan Carlos Izpisúa Belmonte

SELECTED PUBLICATIONS

1.Wang S, Liu Z, Ye Y, Li B, Liu T, Zhang W, Liu GH, Zhang Y, Qu J*, Xu D*, Chen Z*. (*Corresponding author) Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell death and disease. 2018. (in press)

2. Zhang W¹, Wan H¹, Feng G¹, Qu J¹, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu GH, Hu B. (¹equal contribution) SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018. doi:10.1038/s41586-018-0437-z.

3. Zhang W, Song M, Qu J*, Liu GH*. (*Corresponding author) Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018. (in press)

4. Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. (*Corresponding author)

 Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein Cell. 2018 Aug 1.doi: 10.1007/s13238-018-0567-y.

5. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Belmonte JC*, Liu GH*. (*Corresponding author). Differential stem cell aging kinetics in Hutchinson–Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018 Apr; 9(4):333-350. doi: 10.1007/s13238-018-0517-8.

6. Wang S, Hu B, Ding Z, Dang Y,Wu J,Li D,Liu X,Xiao B,Zhang W,Ren R,Lei J,Hu H,Chen C,Chan P,Li D,Qu J*,Tang F*, Liu GH*.(*Corresponding author)ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018 Jan 5. doi:10.1038/s41421-017-0003-0

7. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. (*Corresponding author)CRISPR/Cas9-mediated Gene Knockout Reveals a Guardian Role of NF-κB/RelA in Maintaining the Homeostasis of Human Vascular Cells. Protein Cell. 2018. doi: 10.1007/s13238-018-0560-5

8. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J*,Tang F*,Liu GH*. (*Corresponding author)Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017 Jul 7. doi: 10.1038/cr.2017.86.

9. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*.(*Corresponding author)CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Protein Cell. 2017 May; 8(5):365-378. doi: 10.1007/s13238-017-0397-3.

10. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. (*Corresponding author)Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res. 2017. Jan 31. doi: 10.1038/cr.2017.18.