Name: WANG Yan-Ling

Tel: 64807195

Email: wangyl@ioz.ac.cn

Education:

1993.09-1998.06  Ph.D. in physiology, Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS), Beijing (supervisor: Prof. Lin-zhi Zhuang)

1988.09-1993.07  Bachelor degree, Department of Biology, University of Science and Technology of China, Hefei

Working Experience:

2004.06 -present   Professor, IOZ, CAS, Beijing, China

     2000.10- 2004.05   Associate Professor, IOZ, CAS, Beijing, China

    1998.07- 2000.09   Assistant Professor, IOZ, CAS, Beijing, China

    1999.05-1999.09   Visiting Scholar, HongKong University, HongKong

      Selected Publications:

    1.   Shao X, Tan C, Chen D, Wang YL*. Placental defects are involved in most gene mutations that cause embryonic and fetal death. Biol Reprod. 2018, doi: 10.1093/biolre/ioy080

    2.   Liu M#, Wang Y#, Lu H#, Wang H, Shi X, Shao X, Li Y, Zhao Y* and Wang YL*. mir-518b enhances human trophoblast cell rroliferation through targeting rap1b and activating ras-MAPK signal. Front Endocrinol. 2018, doi: 10.3389/fendo.2018.00100

    3.   Wang H#, Zhang L#, Guo X, Bai Y, Li YX, Sha J, Peng C, Liu M and Wang YL*. MiR-195 modulates oxidative stress-induced apoptosis and mitochondrial energy production in human trophoblasts via FOXRED1 and PDPR. J Hypertens. 2018, 36(2):306-318

    4.   Ma L#, Li G#, Cao G#, Zhu Y, Du MR, Zhao Y, Wang H, Liu Y, Yang Y, Li YX, Li DJ, Yang H, Wang YL*. dNK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C and HGF. Immunol Cell Biol. 2017, 95(8):695-704

    5.   Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Lia YX, Zhao Y*, Wang YL*. Testosterone represses estrogen signaling via upregulating mir-22: mechanism for imbalanced steroid hormone production in preeclampsia. Hypertension, 2017, 69:721-730 (Editorial highlight)

    6.   Wu H#, Wang H#, Liu M, Bai Y, Li YX, Ji L, Peng C, Yu Y*, Wang YL*. MiR-195 participates in the placental disorder of preeclampsia via targeting activin receptor type-2B in trophoblastic cells. J Hypertens. 2016, 34(7):1371-9.

    7.   Luo R#, Wang Y#, Xu P#, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL*. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. Sci Rep, 2016, 6:19588.

    8.   Li S#, Wang Y#, Cao B, Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C, Wang YL*.Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26). J Clin Endo Metab, 2014, 99(11):E2777-87

    9.   Luo R#, Shao X#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C*, Wang YL*. MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1. Hypertension, 2014 64:839-847

    10.   Xu P#, Zhao Y#, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L*, Wang YL*. Variations of microRNAs in human placentas and plasma from preeclamptic pregnancy. Hypertension, 2014, 63:1276-1284.