动物所辉凌生殖健康研究所

HUANG Shiqiang

Date：2018-08-29 【close】

Education:

A.B., Molecular Biology, Princeton University, Princeton, NJ 2005 - 2008

Ph.D., Biomedical Sciences, Harvard Medical School, Cambridge, MA 2009 - 2013

Working Experience:

Junior PI, Genome Institute of Singapore, ASTAR 2013 - 2018

Professor, PI, Regenerative Metabolism Group, Institute of Zoology, CAS 2018 -

Selected Publications:

1. Wu, L.*, Nguyen L. H.*, Zhou, K., de Soysa, T. Y., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T., Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q., Shyh-Chang, N., Zhu, H. (2015). Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 10.7554

2. Khaw, S. L., Min-Wen, C., Koh, C. G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports 12(7), 1080-8.

3. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166(2):451-467.

4. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. S1043-2760(15)00251-9. doi: 10.1016/j.tem.2015.12.006.

5. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. doi:10.1016/j.semcdb.2016.02.005.

6. Fukawa, T., Yan-Jiang,B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016). Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 22(6), 666-71.

7. Andriani Y*, Chua JM*, Chua BY, Phang IY, Shyh-Chang N^#, Tan WS^#. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57, 115-126.

8. Shyh-Chang N and Ng H-H. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4), 336-346.

9. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5), 412-414.

10. Shyh-Chang N. (2018). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026:233-249.