Name: DING Guolian

Subject: Reproductive Medicine

Email: dingguolian@hotmail.com

Education:

2008/09-2011/06 Ph.D., Department of Gynecology and Obstetrics, School of Medicine, Zhejiang University, China

2001/09-2008/09 M.D., Seven-Year Combined Bachelor’s and Master’s Degree Program, School of Medicine, Zhejiang University, China

Work and research experience:

2014/02-present Attending doctor, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine

2011/08-2014/01 Resident doctor-Attending doctor, Women’s Hospital, School of Medicine, Zhejiang University

2018/12-present Member of The Key Laboratory of Embryo Original Diseases, Shanghai, China

2015/10-2016-10 Research Scholar, Baylor College of Medicine, Houston, TX, USA

2014/10-present Member of The Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiao Tong University School of Medicine, China

Honors:

2015, The first prize of National Maternal and Child Health Science and Technology Awards (Reproductive process regulation and molecular mechanism of related disease. Ranking: 8/15）

2013, The National Excellent Doctoral Dissertation Award Nomination

2010, The first prize of Zhejiang Provincial Natural Science Academic Award

Research Grants:

Funding Source: National Natural Science Foundation of China (Grant No. 31571556)

Project name: The mechanism of the influence of estrogen on Pax8 mediated thyroid development and function in offspring

Funding Source: National Natural Science Foundation of China (Grant No. 81200485)

Project name: Intrauterine hyperglycemia environment affects Igf2/H19 gene imprinting of germ cells in male offspring and mechanism involved

Funding Source: Ferring Institute of Reproductive Medicine (FIRM)
Project name: The effect of intrauterine hyperglycemia on the cognitive function in offspring and mechanism involved

Selected Publications:

1.      Jiang Z, Jin L, Shi W, Xi J, Hu Y, Liu X, Sheng J, Ding G*, Huang H*. A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis. Sci China Life Sci. 2019, 62(1):112-118

2.      Ding G, Gong Y, Eckel-Mahan KL, Sun Z. Central Circadian Clock Regulates Energy Metabolism. Adv Exp Med Biol. 2018,1090:79-103.

3.      Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV; DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019, 22(2):205-217.

4.      Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017, 23(2):223-234.

5.      Ding GL^#, Liu Y^#, Liu ME, Pan JX, Guo MX, Sheng JZ, Huang HF. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015, 17(6):948-953

6.      Liu XM^#, Chan HC^#, Ding GL^#, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, Huang HF. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+) /CREB pathway. Aging Cell. 2015, 14(3):409-420

7.      Lv PP, Meng Y, Lv M, Feng C, Liu Y, Li JY, Yu DQ, Shen Y, Hu XL, Gao Q, Dong S, Lin XH, Xu GF, Tian S, Zhang D, Zhang FH, Pan JX, Ye XQ, Liu ME, Liu XM, Sheng JZ, Ding GL^*, Huang HF^*. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. BMC Med. 2014, 12(1):240.

8.      Ding GL, Huang HF. Role for tet in hyperglycemia-induced demethylation: a novel mechanism of diabetic metabolic memory. Diabetes. 2014, 63(9):2906-2908

9.      Ding GL, Huang HF. Paternal transgenerational glucose intolerance with epigenetic alterations in second generation offspring of GDM. Asian J Androl. 2013, 15(4):451-452

10.    Ding GL^#, Wang FF^#, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PC, Sheng JZ, Huang HF. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes. 2012, 61(5):1133-1142