动物所辉凌生殖健康研究所

黄仕强

发布时间：2018-08-29 【关闭】

　　黄仕强研究员

　　博士生导师，再生代谢研究组组长。“青年千人计划”引进海外杰出人才。2008年于普林斯顿大学生物学专业获得最优等荣誉学位。2009-2013年在哈佛医学院获得干细胞生物学博士学位，2013年到2017年在新加坡基因研究所担任研究组组长。2017年加入中科院动物研究所。实验室主要从事肌肉干细胞分化与干细胞代谢的研究。研究成果发表在 Science、Nature Medicine、Cell、Cell Stem Cell、Development 等杂志。承担中国科学院重点部署项目及中科院干细胞先导专项等项目，获得盖茨基金会与HHMI 国际研究学者基金资助。

代谢在干细胞与组织再生中已知的调控机制

发表文献：

1. Wu, L.*, Nguyen L. H.*, Zhou, K., de Soysa, T. Y., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T., Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q., Shyh-Chang, N., Zhu, H. (2015). Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 10.7554

2. Khaw, S. L., Min-Wen, C., Koh, C. G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports 12(7), 1080-8.

3. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166(2):451-467.

4. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. S1043-2760(15)00251-9. doi: 10.1016/j.tem.2015.12.006.

5. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. doi:10.1016/j.semcdb.2016.02.005.

6. Fukawa, T., Yan-Jiang,B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016). Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 22(6), 666-71.

7. Andriani Y*, Chua JM*, Chua BY, Phang IY, Shyh-Chang N^#, Tan WS^#. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57, 115-126.

8. Shyh-Chang N and Ng H-H. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4), 336-346.

9. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5), 412-414.

10. Shyh-Chang N. (2018). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026:233-249.