孙青原

发布时间:2019-03-04

孙青原,中国科学院动物研究所研究员,中国科学院大学岗位教授,国家杰出青年基金获得者,新世纪百千万人才工程国家级人选,“973项目首席科学家。兼任中国动物学会副理事长、生殖生物学分会理事长等。主要从事哺乳动物卵子成熟、受精和早期胚胎发育的遗传和表观遗传研究,在ScienceCellPNASNat Struct Mol BiolNat CommunPLoS GenetDevelopmenteLifeHum Reprod UpdateJCSJBCMBC、、Hum ReprodBiol Reprod Fertil SterilMHR等杂志发表SCI收录论文340余篇,20142018年连续5入选爱思唯尔(Elsevier中国高被引学者榜单。历任Biol ReprodMol Hum ReprodJ Genet GenomicsCell CycleMol Reprod DevReprod Fertil DevJ Reprod Dev等杂志副主编或编委。

Selected Publications:

 

1.      Huang L, Meng TG, Ma XS, Wang ZB, Qi ST, Chen Q, Zhang QH, Liang QX, Wang ZW, Hu MW, Guo L, Ouyang YC, Hou Y, Zhao Y, Sun QY*. Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice. Cell Death Differ2018 Aug 28. doi: 10.1038/s41418-018-0181-9.

2.      Li QN, Li L, Hou G, Wang ZB, Hou Y, Liu ZH, Schatten H, Sun QY*. Glucocorticoid exposure affects female fertility by exerting its effect on the uterus but not on the oocyte: lessons from a hypercortisolism mouse model. Hum Reprod. 2018 Dec 1;33(12):2285-2294. 

3.      Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB*, Sun QY*. Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. 2018 Aug 15:fj201800719R. doi: 10.1096/fj.201800719R.

4.      Li J, Tang JX, Cheng JM, Hu B, Wang YQ, Aalia B, Li XY, Jin C, Wang XX, Deng SL, Zhang Y, Chen SR, Qian WP, Sun QY, Huang XX, Liu YX. Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. J Cell Biol2018 Aug 10. pii: jcb.201802077. doi: 10.1083/jcb.201802077.

5.      Xie B, Zhang L, Zhao H, Bai Q, Fan Y, Zhu X, Yu Y, Li R, Liang X, Sun QY, Li M, Qiao J. Poly(ADP-ribose) mediates asymmetric division of mouse oocyte. Cell Res. 2018, 28: 462-467.

6.      Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, Zhang Z, He X, Zhang Z, Zhou P, Wei Z, Shang Y, Wang L, Zhang R, Ouyang YC, Sun QY, Cao Y, Li W. Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome. Am J Hum Genet2018 Aug 2;103(2):188-199.

7.      Zhang T, Zhou Y, Li L, Wang ZB, Shen W, Schatten H, Sun QY*. CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Development. 2017 Jan 15;144(2):305-312.

8.      Shang Y, Zhu F, Wang L, Ouyang YC, Dong MZ, Liu C, Zhao H, Cui X, Ma D, Zhang Z, Yang X, Guo Y, Liu F, Yuan L, Gao F*, Guo X*, Sun QY*, Cao Y*, Li W*. Essential role for SUN5 in anchoring sperm head to the tail. Elife. 2017 Sep 25;6. pii: e28199. doi: 10.7554/eLife.28199.

9.      Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X*, Wang ZB*, Sun QY*Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. 2016 Dec 8;12(12):e1006513. doi: 10.1371/journal.pgen.1006513.

10.    Qi ST, Ma JY, Wang ZB, Guo L, Hou Y, Sun QY*N6-methyladenosine seqencing highlights the involvement of mRNA methylation in oocyte meiotic maturation and embryo development by regulating translation in Xenopus laevis. J Biol Chem. 2016 Oct 28;291(44):23020-23026.