姓名: 丁国莲

专业: 生殖医学

邮箱: dingguolian@hotmail.com

教育经历:

2008/09－2011/06，浙江大学，妇产科学，博士

2001/09－2008/06，浙江大学，临床医学七年制

工作科研经历:

2014/02－至今，上海交通大学医学院附属国际和平妇幼保健院，主治医师

2011/08－2014/01，浙江大学医学院附属妇产科医院，住院医师－主治医师2018/12－至今，上海市胚胎源性疾病重点实验室，研究骨干

2015/10－2016/09，美国Baylor医学院，访问学者

2014/10－至今，上海交通大学医学院胚胎源性疾病研究所，研究骨干

获奖:

2015年全国妇幼健康科学技术奖一等奖（8/15）

2013全国优秀博士学位论文提名论文

2010浙江省自然科学学术奖一等奖

科研项目:

国家自然科学基金 (31571556)

雌激素对Pax8介导的子代甲状腺发育及功能的影响机制研究

国家自然科学基金 (81200485)

宫内高糖环境对雄性子代生殖细胞Igf2/H19基因印记的影响及其机制研究

辉凌生殖医学研究院（FIRM）项目

宫内高糖环境对子代认知功能的影响及机制研究

部分代表性论文:

1.      Jiang Z, Jin L, Shi W, Xi J, Hu Y, Liu X, Sheng J, Ding G*, Huang H*. A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis. Sci China Life Sci. 2019, 62(1):112-118

2.      Ding G, Gong Y, Eckel-Mahan KL, Sun Z. Central Circadian Clock Regulates Energy Metabolism. Adv Exp Med Biol. 2018,1090:79-103.

3.      Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV; DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019, 22(2):205-217.

4.      Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017, 23(2):223-234.

5.      Ding GL^#, Liu Y^#, Liu ME, Pan JX, Guo MX, Sheng JZ, Huang HF. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015, 17(6):948-953

6.      Liu XM^#, Chan HC^#, Ding GL^#, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, Huang HF. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+) /CREB pathway. Aging Cell. 2015, 14(3):409-420

7.      Lv PP, Meng Y, Lv M, Feng C, Liu Y, Li JY, Yu DQ, Shen Y, Hu XL, Gao Q, Dong S, Lin XH, Xu GF, Tian S, Zhang D, Zhang FH, Pan JX, Ye XQ, Liu ME, Liu XM, Sheng JZ, Ding GL^*, Huang HF^*. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. BMC Med. 2014, 12(1):240.

8.      Ding GL, Huang HF. Role for tet in hyperglycemia-induced demethylation: a novel mechanism of diabetic metabolic memory. Diabetes. 2014, 63(9):2906-2908

9.      Ding GL, Huang HF. Paternal transgenerational glucose intolerance with epigenetic alterations in second generation offspring of GDM. Asian J Androl. 2013, 15(4):451-452

10.    Ding GL^#, Wang FF^#, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PC, Sheng JZ, Huang HF. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes. 2012, 61(5):1133-1142