赵涵
个人简介：
赵涵，山东大学附属生殖医院教授，主任医师，博士生导师，教育部生殖内分泌重点实验室副主任，试管婴儿胚胎实验室主任。从事生殖医学临床、科研及教学工作十余年，是国家自然基金“优秀青年”项目、教育部新世纪优秀人才、教育部长江学者青年学者和山东省自然基金“杰出青年”项目获得者，目前兼任中国医师协会生殖医学分会青年委员会副主任委员，中国生理学会生殖科学专业委员会委员，山东省医师协会青春期医学专业委员会副主任委员和山东省医学会妇产科学分会青年委员等职。近年来，主持国家自然基金优秀青年项目、面上项目，科技部重点专项子课题，NIH-R01等十余项课题。在Nat Genet、Cell Res、Am J Hum Genet、PNAS等国际知名杂志发表SCI论文40多篇，首次在国际上报道了遗传性空卵泡综合征的致病基因，率先开展了人类极体移植、前原核移植等四代试管婴儿技术。擅长多囊卵巢综合征、卵子或胚胎发育异常、卵巢早衰、闭经、习惯性流产、胚胎反复着床失败等生殖内分泌疾病的诊治，并擅长第三代试管婴儿、第四代试管婴儿技术和遗传疾病的子代风险评估。
联系方式：
通讯/办公地址 : 山东省济南市市中区经六纬五路157号山东大学附属生殖医院；邮编: 250001
邮箱: folisun@126.com
教育经历
2008.10--2010.10山东大学，博士后，导师：赵跃然
2006.6--2008.1 美国贝勒医学院，妇产科学，Pre Doc-Fellow
2003.9 -- 2008.7 山东大学 妇产科学（硕博连读），导师：陈子江
1998.9 -- 2003.7 山东大学 临床医学（本科）
研究方向
1、多囊卵巢综合征遗传学研究
2、卵母细胞发育障碍机制研究
Selected Publications:
1. Chen ZJ, Zhao H*, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011 Jan;43(1):55-9.
2. Shi Y*, Zhao H*, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L, Chen ZJ. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012 Sep;44(9):1020-5.
3. Zhao H*, Xu X, Xing X, Wang J, He L, Shi Y, Shi Y, Zhao Y, Chen ZJ. Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Hum Reprod. 2012 Jan;27(1):294-8.
4. Zhao H*, Xu J, Zhang H, Sun J, Sun Y, Wang Z, Liu J, Ding Q, Lu S, Shi R, You L, Qin Y, Zhao X, Lin X, Li X, Feng J, Wang L, Trent JM, Xu C, Gao Y, Zhang B, Gao X, Hu J, Chen H, Li G, Zhao J, Zou S, Jiang H, Hao C, Zhao Y, Ma J, Zheng SL, Chen ZJ. A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. American journal of human genetics. 2012; 90(5):900-6.
5. Cui L, Zhao H*, Zhang B, Qu Z, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Wang P, Li T, Shi Y, Chen ZJ. Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women. Hum Reprod. 2013 Feb;28(2):538-44.
6. Zhao H* Chen ZJ. Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping. Molecular human reproduction.2013; 19(10):644-54.
7. Cui L, Li G, Zhong W, Bian Y, Su S, Sheng Y, Shi Y, Wei D, Zhang W, Zhao H*, Chen ZJ. Polycystic ovary syndrome susceptibility single nucleotide polymorphisms in women with a single PCOS clinical feature. Hum Reprod. 2015 Mar;30(3):732-6.
8. Yuan X*, Hu T*, Zhao H*, Huang Y, Ye R, Lin J, Zhang C, Zhang H, Wei G, Zhou H, Dong M, Zhao J, Wang H, Liu Q, Lee HJ, Jin W, Chen ZJ. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2708-13.
9. Tian Y*, Zhao H*,, Chen H, Peng Y, Cui L, Du Y, Wang Z, Xu J, Chen ZJ. Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women. The Journal of clinical endocrinology and metabolism. 2016; 101(5):2178-84.
10. Zhao H, Lv Y, Li L, Chen ZJ. Genetic Studies on Polycystic Ovary Syndrome. Best practice & research. Clinical obstetrics & gynaecology. 2016; 37:56-65.